Program

Wednesday - July 3rd, 2019

Time Sala Baldaquino Sala Fogón
08:00 Technical Secretariat opens for Registration
09:00 - 11:00 Session 1:
New in vivo tools in Pharmacology: CRISPR/Cas and conditional mice

Moderators: Mª Ángeles Moro and Lluis Montoliu
Speakers:
- "New Animal Models with CRISPR Tools". Lluís Montoliu. CNB. Madrid, Spain
- “Conditional Mouse Models, Strategies and Applications”. Sagrario Ortega. CNIO. Madrid, Spain
- "Investigation of Rodent Adult Neurogenesis in Homeostasis and Disease: an example of the use of Conditional Mice in Neuropharmacology".
Mª Ángeles Moro. Universidad Complutense. Madrid, Spain
11:00 - 12:00 Coffee Break
12:00 - 12:30 Opening Ceremony
12:30 - 13:30 Opening Lecture
- "Stop the Mast Cells and the Eosinophils by any means!". Francesca Levi-Schaffer. IUPHAR, Jerusalem, Israel
13:30 - 15:00 Lunch
15:00 - 16:00 Plenary Lecture
- "Protease-Activated Receptors (PARs) in Inflammation and Pain: What should we target?". Nathalie Vergnolle. INSERM. Toulouse, France
16:00 - 16:30 Coffee Break and Poster Session 1
16:30 - 18:30 Session 2:
New targets in cardiac and cardiovascular disorders

Moderators: Ricardo Caballero and Thomas Wieland
Speakers
- "Targeting Histidine Phosphorylation by Nucleoside Diphosphate Kinases in Cardiovascular Disease". Thomas Wieland. Heidelberg University. Mannheim, Germany
- "Interventions in WNT Signaling Ctimulate Cardiac Regeneration". Mattijs Blankesteijn. Maastricht University. Maastricht, Netherland
- "Recent Advances in the Pharmacological Treatment of Cardiovascular Diseases". Ricardo Caballero. Universidad Complutense. Madrid, Spain

Oral communications
Abstracts Title:
- "Systemic Inflammation is Reduced in Primary Hypercholesterolemia Patients after an Oral Fat Load Administration". Aida Collado. Universidad de Valencia. Valencia, Spain
- "Probiotics Prevent Hypertension in a Murine Model of Systemic Lupus Erythematosus Induced by TLR7 Activation" Néstor De La Visitación. Universidad de Granada. Granada, Spain
Session 3:
Parallel Roundtable. Education in Pharmacology

Moderators: Michael Spedding and Concha Peiró
Speakers
- "IUPHAR, Education and Collaborations World-Wide" Michael Spedding, IUPHAR, Edimburgh, UK
- "The Doctoral Programme in Pharmacology, University of Chile". Guillermo Díaz. Universidad de Chile. Santiago, Chile
-"Doctoral Studies in Spain: Structure and Management". Jose Miguel Doña. ULPGC. Las Palmas de Gran Canaria, Spain

Oral communications
Abstracts Title:
- "Combination of Innovative Teaching Techniques in Pharmacology Seminar Classes". Mª Carmen Montesinos. Universidad de Valencia. Valencia, Spain
- "Information about Drugs and Related Topics in the Spanish General, Economic and Professional Press". Gonzalo Casino. Universitat Pompeu Fabra. Barcelona, Spain
20:30 Welcome Reception

Thursday - July 4th, 2019

Time Sala Baldaquino Sala Fogón
08:00 Technical Secretariat opening time
09:00 - 11:00 Session 4:
Open innovation in drug discovery

Moderator: María Jesús Sanz.
Speakers:
- "Health Care and Impact of Migraine from the Patients Perspective". Isabel Colomina. AEMICE. Madrid, Spain
- "Migraine Pharmacology Evolution". María del Buensuceso Fernández del Pozo. Consejo General de Colegios Oficiales de Farmacéuticos. Madrid, Spain
- Physiopathology and epidemiology of Migraine". Ayoze González. Hospitales San Roque. Las Palmas de Gran Canaria, Spain
Sponsored by NOVARTIS
Session 5:
Young Scientist Forum
Part 1

Moderators: Cristina Arce, Marta Cimadevila and Aida Collado
Speaker:
- "Creativity in Science". Michael Spedding. IUPHAR, Edimburg, UK
Part 2
Moderators: Jesús Cosín, Patrice Marques, Alejandra Romero and Álvaro San Hipólito
Speakers:
- "How to become a good University Professor". María Luisa Ferrándiz. Universidad de Valencia, Valencia, Spain
- "Research after PhD". Nuria Godessart. Almirall, Barcelona, Spain
- "From Science to Industry". Amadeu Gavaldá. Almirall, Barcelona, Spain
- "How to bring Science to Society: from School to Parliament". Eduardo Oliver. CNIC, Madrid, Spain
Sponsored by Almirall
11:00 - 11:30 Coffee Break and Poster Session 2
11:30 - 13:30 Session 6:
New advances in the Pharmacology of Respiratory System
.
Moderators: Angel Cogolludo and Andreas Ludwig
Speakers:
- “Targeting K+ Channels in Pulmonary Hypertension”. Ángel Cogolludo. Universidad Complutense. Madrid, Spain
- "ADAM Family Proteases: Friends or Foes in Pulmonary Inflammation?" Andreas Ludwig. RWTH Aachen University. Aachen, Germany

Oral communications
Abstracts Title:
- "Role of il-11 in Pulmonary Fibrosis Associated to Pulmonary Hypertension". Inés Roger. CIBERES. Madrid, Spain
- "The Role of MUC1 in a Bleomycin Induced Pulmonary Fibrosis Mouse Model". Paula Montero Magalló. INCLIVA. Valencia, Spain
Session 7:
New advances in Neuropharmacology

Moderators: Ricardo Borges and Ramón Sotomayor
Speakers:
- "Inside a Secretory Vesicle. Novel Targets for Modulating the Exocytosis of Neurotransmitters". Ricardo Borges Jurado. ULL. Tenerife, Spain
- "Pamam Dendrimers Effects on Neuronal Functionality in vitro". José Guzmán González. Universidad de Concepción. Concepción, Chile
-"Programming of Dopaminergic Neurons by Early Exposure to Sex Hormones: is a Vulnerability Factor for Drug Addiction?". Ramón Sotomayor Zárate. Universidad de Valparaíso. Valparaíso, Chile
- "Supplementation with Melatonin Impedes Cognitive Decline in tau-related Alzheimer Models, by Restoring the Autophagic Flux, once the Pathology is Initiated". Izaskun Buendía Abaitua. UAM. Madrid, Spain
13:30 - 15:00 Lunch
15:00 - 16:00 Plenary Lecture
"Somatic Mutations and Clonal Hematopoiesis as Drivers of Inflammation and Cardiovascular Disease". José Javier Fuster. CNIC. Madrid, Spain
16:00 - 16:30 Coffee Break and Poster Session 3
16:30 - 18:30 Session 8:
Free Radicals in traslational Pharmacology.

Moderators: María José Alcaraz and Pietro Ghezzi
Speakers:
- "Relevance of Nrf2 and Heme Oxygenase-1 in Articular Disease". María José Alcaraz. Universidad de Valencia. Valencia, Spain
- “Free Radicals in Translational Pharmacology: NOS, NOX & sGC as a Network Pharmacology-Based Approach for Brain Ischemia”. Ana Casas. Maastricht University. Maastricht, Netherlands
- "The Oxidative Stress Theory of Disease". Pietro Ghezzi. Brighton & Sussex Medical School. Sussex, UK

Oral communications
Abstracts Title:
- "Evaluation of Nrf2 Activators for the Treatment of Chronic Obstructive Pulmonary Disease (COPD)". Cristina Estornut. Universidad de Valencia. Valencia, Spain
- "Adipose Tissue Mesenchymal Stem Cell-Derived Extracellular Vesicles as a Biological Therapy in Osteoarthritic Cells". Miguel Tofiño-Vian. Universidad de Valencia. Valencia, Spain
Session 9:
Poster Presentation (8 selected posters)

Moderators: Mabel Loza and Juan Manuel Duarte
Abstracts Titles:
- "CCL11/CCR3 Axis is Involved Atherosclerosis Development". Elena Domingo. Universidad de Valencia. Valencia, Spain
- "The Adipokine Visfatin Induces Endothelial Dysfunction through TLR-4 and NLRP3 Inflammasome Activation". Álvaro San Hipólito-Luengo. UAM. Madrid, Spain
- "Characterization and Evaluation of Hemp Protein Hydrolysates on Neuroprotection". Sergio Montserrat De La Paz. Universidad de Sevilla. Sevilla, Spain
- "Obesity-Induced Hypogonadism: Pathophysiological Roles of a Novel Hypothalamic miRNA/Kisspeptin Pathway and Potential Therapeutic Implications". Mª Soledad Avendaño. Universidad de Córdoba. Córdoba, Spain
- "In vitro Characterization of a TRPV1 Soft Antagonist". Magdalena Nikolaeva Koleva. IDiBE. Elche, Spain
- "Quantification of Functional Bias of Serotonin 5-HT2A Receptor Agonists and Validation of Structural Hypotheses on Functional Selectivity at 5-HT2A Receptor". Andrea García Silva. Universidad de Santiago de Compostela. Santiago de Compostela, Spain
- "MUC1-CT as an IPF Potential Druggable Target". Beatriz Ballester. Universidad de Valencia. Valencia, Spain
- "Mechanisms of Resistance to Egfr-Targeted Therapy Induced by Nicotine in Human Lung Cancer". María Extremera Mazuela. UAM. Madrid, Spain

Friday - July 5th, 2019

Time Sala Baldaquino Sala Fogón
08:00 Technical Secretariat opening time
09:00 - 11:00 Session 10:
Aging from Mechanisms to Pharmacological Perspectives

Moderators: José Viña and Jorge Fuentealba
Speakers:
- "Aging from Mechanisms to Pharmacological Perspectives". José Viña. Universidad de Valencia. Valencia, Spain
- "P2XR Overexpression Contribute to Beta Amyloid Toxicity: New Pharmacological Target to AD". Jorge Fuentealba Arcos. Universidad de Concepción. Concepción, Chile
- "Cardiac Fibroblast Role on Inflammatory Process: Interaction with Immune Cells". Guillermo Díaz. Universidad de Chile. Santiago, Chile

Oral communications
Abstracts Title:
- "Targeting Soluble Epoxide Hydrolase to Improve Neurodegenerative Traits in SAMP8 Mouse". Mercè Pallàs. Universidad de Barcelona. Barcelona, Spain
- "The Angiotensin-(1-7)/Mas Receptor Axis Attenuates Human Endothelial Cells Senescence through the Activation of Klotho and Nrf2". Alejandra Romero Martínez. UAM. Madrid, Spain
Session 11:
New Advances in the Pharmacology of Cancer

Moderators: Francisco Estévez Sarmiento and Patricia Rijo
Speakers:
- "Abietane Diterpenoids from Plectranthus spp. as Lead Protein Kinase C Modulators for Cancer Therapy". Patricia Rijo. Universidade Lusófona. Lisboa, Portugal
- "Sesquiterpene Lactones as Potential Agents against Cancer". Francisco Estévez Sarmiento. ULPGC. Las Palmas de Gran Canaria, Spain
-"Novel Biomarkers and Therapeutic Targets in Clear Cell Renal Cell Carcinoma (ccRCC)" Anna Meseguer Navarro. VHIR. Barcelona, Spain

Oral communications
Abstracts Title:
- "CM-728 as a Potential and Novel Compound for Metastatic Clear Cell Renal Cell Carcinoma (ccRCC) Treatment". Jazmine Arévalo. Universitat Autònoma de Barcelona. Barcelona, Spain
- "Preliminary Screening for Selective Anticancer Activity of Andalusian Plants". Víctor Jiménez González. Universidad de Sevilla. Sevilla, Spain
11:00 - 11:30 Coffee Break
11:30 - 12:30 Session 12
Oral Communications: Pain and Inflammation

Moderators: Francesca Levi-Schaffer and Eva Delpón
Abstracts Title:
- "Amitriptyline, a New Therapeutic Tool to Block Innate Immune Responses in Osteoarthritis Patients". Eloi Franco Trepat. Instituto IDIS. Madrid, Spain
- "Methadone is an analgesic with Low Addictive Side Effects due to its Weak Potency on Opioid-Galanin Receptor Heteromers".
Verónica Casadó. Universidad de Barcelona. Barcelona, Spain
- "Identification and Validation of two small Molecules Targeting the IL-17 Inflammatory Pathway". Elia Álvarez Coiradas. Universidad de Santiago de Compostela. Santiago de Compostela, Spain
Session 13
Oral Communications: Neuro/Psychopharmacology and Receptors

Moderators: Paco Ciruela and Mattijs Blankesteijn
Abstracts Title:
- "Protective Effect of Phosphorus Dendrimers in a Murine Model of Multiple Sclerosis". Valentín Ceña. Universidad de Castilla-La Mancha. Castilla-La Mancha, Spain
- "NLRP3 Inflammasome Inhibition Protects the Neurovascular Unit, Reduces Infarct Volume and Inflammation in Cerebral Ischemia". Alejandra Palomino Antolín. IIS Princesa. Madrid, Spain
- "Cannabidiol Antidepressant-Like Effects in Rats: Decreased Sensitivity in Adolescent versus Adult Rats". Mª Julia García Fuster. Universitat de les Illes Balears. Palma de Mallorca, Spain
- "Essential Role of C148-C227 Disulfide Bridge in Human 5-HT2A Receptor Functionality and Trafficking". Marta Cimadevila. University of Santiago de Compostela. Santiago de Compostela, Spain
12:30 - 13:30 Closing Lecture
"Resolution Pharmacology" Mauro Perretti. Queen Mary University of London. London, UK
Sponsored by EPHAR
13:30 - 14:00 Closing Ceremony
15:30 - 17:30 SEF Assembly